Stricturing Crohn’s disease-like colitis in a patient treated with belatacept
نویسندگان
چکیده
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) modifying agents have been involved in the development of intestinal inflammation, especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept, a recombinant CTLA-4-Ig fusion protein.
منابع مشابه
The unusual presentation of genital Crohn’s disease in a patient with breast cancer: A case report
Cutaneous Crohn’s disease (CCD) is a relatively rare disease. Two-thirds of the affected patients are female with a mean age of onset of 35 years. CCD is divided into a genital type and an extra-genital type, each with their own unique different clinical manifestations. The usual presentation of genital Crohn’s disease (CD) is in the form of erythema and edema of the labia and scrotum. Here, we...
متن کاملINFLAMMATORY BOWEL DISEASE Early development of stricturing or penetrating pattern in Crohn’s disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype
Background: Crohn’s disease is a heterogeneous entity. Disease behaviour, characterised as stricturing, penetrating, or non-stricturing non-penetrating, is a clinically important phenotype as it is associated with complications and need for surgery. It has recently been showed that the behaviour of Crohn’s disease changes over the course of the disease. Aim: To assess the association between ra...
متن کاملINFLAMMATORY BOWEL DISEASE Anti-Saccharomyces cerevisiae antibodies in twins with inflammatory bowel disease
Background and aims: An increased occurrence of anti-Saccharomyces cerevisiae antibodies (ASCA) is reported in unaffected members of families with Crohn’s disease. Whether ASCA is a familial trait due to genetic factors or is caused by exposure to environmental factors is unknown. To assess the genetic influence of ASCA we studied its occurrence in a twin population. Patients and methods: ASCA ...
متن کاملIsolated cutaneous Crohn’s disease: A case report
This case report describes a patient with cutaneous signs in the genital and peri-anal region suspicious of Crohn’s disease without any intestinal symptom or sign. Inflammatory bowel disease can be associated with some cutaneous signs. However, in this paper, we report a patient with isolated cutaneous Crohn’s disease which is very rare (less than 100 case reports across the world). Our patient...
متن کاملMucormycosis Pneumonia in an Ulcerative Colitis Patient: A Case Report
Background and Objectives: Ulcerative Colitis is an inflammation of colon mucosa that is treated by corticosteroids. Our aim in this study was to report a case of immunodeficiency in this disease caused by long-term corticosteroid treatment. Case Report: This study was a case report of ulcerative colitis patient, who has been using prednisolone from five years ago till now without the doctor's...
متن کامل